diff -r bac92fcfe4d7 c/_cffi_backend.c
--- a/c/_cffi_backend.c	Mon Jul 18 15:58:34 2022 +0200
+++ b/c/_cffi_backend.c	Sat Aug 20 12:38:31 2022 -0700
@@ -96,7 +96,7 @@
 # define CFFI_CHECK_FFI_PREP_CIF_VAR 0
 # define CFFI_CHECK_FFI_PREP_CIF_VAR_MAYBE 0
 
-#elif defined(__APPLE__) && defined(FFI_AVAILABLE_APPLE)
+#elif defined(__APPLE__)
 
 # define CFFI_CHECK_FFI_CLOSURE_ALLOC __builtin_available(macos 10.15, ios 13, watchos 6, tvos 13, *)
 # define CFFI_CHECK_FFI_CLOSURE_ALLOC_MAYBE 1
@@ -6413,7 +6413,7 @@
     else
 #endif
     {
-#if defined(__APPLE__) && defined(FFI_AVAILABLE_APPLE) && !FFI_LEGACY_CLOSURE_API
+#if defined(__APPLE__) && !FFI_LEGACY_CLOSURE_API
         PyErr_Format(PyExc_SystemError, "ffi_prep_closure_loc() is missing");
         goto error;
 #else